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The show centers on Jaye Tyler, a recent Brown University graduate with a philosophy degree, who holds a dead-end job as a sales clerk at a Niagara Falls gift shop. Jaye is the reluctant participant in conversations with various animal figurines — a wax lion, brass monkey, stuffed bear, and mounted fish, among others — which direct her via oblique instructions to help people in need.
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La Ciudad de las Estrellas, a tiny town in the South American jungle, is home to an understaffed, understocked medical clinic where three idealistic doctors come looking for change.